A high-performance liquid chromatography method using UV detection for determination of gabapentin in human serum has been developed. Serum was deproteinized with acetonitrile, and supernatant was evaporated. Derivatization was performed using 4-nitrophenylisothiocyanate, and separation was achieved on a C(18) column with detection at 335 nm. The method was linear in the 0.12-6.0 microg/mL range. No interference was found from endogenous amino acids. The method is suitable for routine therapeutic drug monitoring and for pharmacokinetic studies.
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Rouini et al. (2010) studied this question.
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