Key result
Mental disorders such as depression and anxiety may exacerbate Type 2 diabetes complications by inducing chronic inflammation through the activation of pro-inflammatory molecules and pathways.
This review highlights a plausible mechanistic link where mental disorders like depression and anxiety exacerbate Type 2 diabetes complications through the induction of chronic inflammation.
May warrant mental health assessment in T2D; leaves open confirmation of inflammation-targeted interventions in trials.
Mental disorders including depression and anxiety are the prevalent human diseases which are associated with several metabolic and non-metabolic diseases. Recent investigations demonstrated that the mental disorders can be considered as the potential inducers/stimulators of chronic inflammation. Based on the fact that chronic inflammation is a main cause of human diseases, hence, a hypothesis has been raised to explore the interaction between mental disorders and inflammation related metabolic diseases. Type 2 diabetes (T2D), as a complicated metabolic disorder, is associated with inflammation and also mental disorders. Accordingly, it has been hypothesized that depression and anxiety, as mental disorders may be the inducers/stimulators of inflammation in the patients suffering from T2D. This review article collected recent information regarding the roles of mental disorders on the chronic inflammation in the T2D patients.
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Hajebrahimi et al. (2016) conducted a review in Type 2 diabetes and mental disorders (depression, anxiety). Mental disorders (depression and anxiety) was evaluated. Mental disorders such as depression and anxiety may exacerbate Type 2 diabetes complications by inducing chronic inflammation through the activation of pro-inflammatory molecules and pathways.
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