Concentrations of Meprobamate in the Blood and Liver Following Fatal Meprobamate Poisoning

The concentrations of meprobamate in the blood and liver were determined in 12 cases of death due to meprobamate poisoning and in 29 cases of death due to the combined effects of meprobamate and alcohol, meprobamate and barbiturate, or meprobamate, alcohol and barbiturate. In the cases of poisoning from meprobamate alone, the blood meprobamate concentrations were within the range of 142–342 μg/ml (mean value: 226 μg/ml). In the cases of poisoning with a combination of the drugs, the blood meprobamate concentrations were: for meprobamate and alcohol, 43–155 μg/ml (mean value 117 μg/ml); for meprobamate and barbiturate, 30–276 μg/ml (mean value 117 μg/ml); for meprobamate, barbiturate and alcohol, 33–460 μg/ml (mean value 133 μg/ml).