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This editorial discusses the complex genetic and non-genetic risk factors contributing to aortic valve stenosis, highlighting the lack of compelling treatments prior to valve replacement.
This editorial discusses the complex etiology of aortic stenosis, highlighting the lack of medical therapies to prevent progression to valve replacement.
This editorial refers to ‘Lipoprotein(a), LDL-cholesterol, and hypertension: predictors of the need for aortic valve replacement in familial hypercholesterolaemia’†, by L. Perez de Isla et al., on page 2201. Although aortic stenosis is one of the most frequent cardiovascular diseases, we do not have really compelling concepts of how to successfully treat this disease except the final stage which ends in valve replacement therapy. Often aortic stenosis is a consequence of other cardiovascular diseases such as coronary artery disease and hypertension. However, these are themselves a consequence of a myriad of risk contributors as is characteristic of a complex disease with its orchestra of genetic and non-genetic factors. The composition of the orchestra finally decides whether we will hear a euphonious lifelong theme or a disharmonious cacophony resembling a nightmare which becomes true. Finding the real culprit or culprits in this orchestra is not easy and...
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Florian Kronenberg (2020) conducted an editorial in Aortic valve stenosis. This editorial discusses the complex genetic and non-genetic risk factors contributing to aortic valve stenosis, highlighting the lack of compelling treatments prior to valve replacement.