Key result
Single oral doses of procaterol were therapeutically effective in asthmatic children, with the 1.5 micrograms/kg dose producing sustained bronchodilation but increased incidence of tremors.
Why the study?
Does single-dose oral procaterol improve bronchodilation in asthmatic children?
RCT (n=16)
Double-blind
Does single-dose oral procaterol improve bronchodilation in asthmatic children?
A single oral dose of 0.5 micrograms/kg procaterol provides an effective bronchodilating effect with a reasonable risk/benefit ratio in asthmatic children.
Supports 0.5 μg/kg oral procaterol for balanced efficacy-tolerability in children; extends pediatric RCT dose-response data.
A double-blind crossover study was performed to evaluate the bronchodilating effect of different single doses of procaterol (less than 0.5 micrograms/kg, 1.5 micrograms/kg, and placebo) orally administered. Sixteen asthmatic children, age 6-12 years, participated in the trial. Pulmonary function, heart rate, blood pressure, and tremor were evaluated at 30, 60, 90, and 120 min and then hourly for 8 hours after administration. All three doses were therapeutically effective. The 1.5 micrograms/kg dose produced a more sustained bronchodilatation effect, but was also associated with an increase in the incidence of tremors. The 0.5 micrograms/kg dosage may, however, be a good starting dose because it assures a reasonable risk/benefit ratio.
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Boner et al. (1990) conducted an RCT in Asthma (n=16). Oral procaterol vs. Placebo was evaluated on Bronchodilating effect. Single oral doses of procaterol were therapeutically effective in asthmatic children, with the 1.5 micrograms/kg dose producing sustained bronchodilation but increased incidence of tremors.
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