Genetic analysis reveals a gain-of-function STAT3 mutation in lymphocytic hypereosinophilic syndrome, indicating a clonal driver of abnormal eosinophilia.
To the editor: Hypereosinophilic syndrome (HES) is a heterogeneous group of disorders characterized by (1) persistent peripheral eosinophilia, (2) target organ pathology mediated by infiltrating eosinophils, and (3) the absence of known infectious or allergic causes of hypereosinophilia.[1][1],[2][
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Walker et al. (2015) studied this question.
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