We have examined the haemolytic activity of polyamidoamine dendrimers. Haemolysis increased in a generation- and concentration-dependent manner. Moreover, the longer the incubation time, the greater the amount of haemoglobin released. When human serum albumin (HSA) was present in the incubation buffer, the extent of haemolysis decreased. This protective effect may be due to the high affinity of dendrimers for proteins: dendrimers that interact with HSA are unable to disrupt the membrane to the same extent as free dendrimers. The presence of HSA makes the buffer more relevant to physiological conditions. The results of this study suggest that the actual haemotoxicity of dendrimers in vivo is lower than is observed in vitro .
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Klajnert‐Maculewicz et al. (2009) studied this question.
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