Key result
A methodological framework was proposed to establish a core outcome set for cardiovascular diabetology using systematic reviews, Delphi surveys, and expert consensus meetings.
Why the study?
Heterogeneity of outcomes among trials limits comparison of results, and some outcomes are not always meaningful to end-users in cardiovascular diabetology.
This paper outlines a methodological framework for developing a core outcome set (COS) in cardiovascular diabetology to standardize outcome reporting in future clinical trials.
May guide standardized outcome reporting in future trials; leaves open validation and adoption in cardiovascular diabetology research.
Background: Cardiovascular diabetology is an emergent field focusing on all aspects of diabetes/cardiovascular interrelationship and metabolic syndrome. High-quality evidence needs to be provided to determine the efficacy and safety of interventions in cardiovascular diabetology. The heterogeneity of outcomes among trials limits the comparison of results, and some outcomes are not always meaningful to end-users. The cardiovascular diabetology core outcome set (COS) study aims to develop a COS of interventions for cardiovascular diabetology. In this paper, we introduce the methodological framework for developing the COS. Methods: The COS development will include the following steps: (a) establish the COS groups of stakeholders, including international steering committee, Delphi survey group, and consensus meeting group; (b) systematic reviews of outcomes used in trials of cardiovascular diabetology; (c) semistructured interview of stakeholders for outcomes of cardiovascular diabetology; (d) generate a list of candidate outcomes and determine the original outcome pool; (e) Delphi survey with stakeholders of cardiovascular diabetology to select potential core outcomes; and (f) review and endorse the cardiovascular diabetology COS by expert consensus meeting. Conclusions: This current study reports the methodological framework to develop a COS in cardiovascular diabetology and will provide evidence for the future development of COS in cardiovascular diabetology.
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Jiao et al. (2023) studied Cardiovascular diabetology. Core outcome set development framework was evaluated. A methodological framework was proposed to establish a core outcome set for cardiovascular diabetology using systematic reviews, Delphi surveys, and expert consensus meetings.
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