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Ischemic infarction was obtained in the basal ganglia and internal capsule of the Rhesus monkey by clipping the middle cerebral artery at its origin through a transorbital approach. The postmortem microvasculature was demonstrated using microtized barium (Micropaque) and soft x-ray technology. The effects on this microvasculature induced by antemortem variations in Pa co co2 in tne normal and the acutely infarcted animal were studied. Microangiography was shown to be useful in the study of dynamic vascular changes in the deep structures of the ischemic brain.
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Harrington et al. (1972) studied this question.
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