Key result
Intravenous terlipressin induced a prolonged QT interval and torsade de pointes in a 50-year-old male, which resolved after a 300-J counter-shock and drug discontinuation.
Why the study?
Does intravenous terlipressin cause ventricular arrhythmia in a patient with risk factors for acquired long QT syndrome?
Case Report (n=1)
Does intravenous terlipressin cause ventricular arrhythmia in a patient with risk factors for acquired long QT syndrome?
Intravenous terlipressin can induce prolonged QT interval and torsade de pointes, particularly in patients with risk factors for acquired long QT syndrome such as mineral dysbalance and hepatic impairment.
Terlipressin may trigger TdP in patients with acquired long QT risk factors; hypothesis-generating from one case and needs confirmation.
During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding, a 50-year-old male with no history of heart disease developed a newly prolonged QT interval and torsade de pointes. Risk factors present for acquired long QT syndrome were mineral dysbalance and a history of alcohol abuse with hepatic impairment. The patient was brought back to a normal sinus rhythm after a single 300-J counter-shock. Terlipressin was discontinued, and the patient's QTc interval subsequently returned to baseline. During 6 weeks of monitoring, arrhythmia did not recur.
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Ürge et al. (2008) conducted a case report in Recurrent gastrointestinal bleeding (n=1). Terlipressin was evaluated on Prolonged QT interval and torsade de pointes. Intravenous terlipressin induced a prolonged QT interval and torsade de pointes in a 50-year-old male, which resolved after a 300-J counter-shock and drug discontinuation.
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