gamma-Hydroxybutyrate and ethanol, as well as gamma-butyrolactone and ethanol are potentiative with respect to duration of loss of the righting reflex (sleep time). The concentration of ethanol in the liver decreases from 30 to 90 minutes after rats are injected with ethanol, but there is no change when ethanol is injected with gamma-butyrolactone. In view of the fact that gamma-hydroxybutyrate is a natural intermediate in brain, the effects of ethanol on the central nervous system may be mediated through its interaction with gamma-butyrolactone.
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McCabe et al. (1971) studied this question.
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