Key result
A reduced pre-operative functional mucosal surface independently predicted the early occurrence of multiple organ dysfunction after cardiac surgery.
Why the study?
Does reduced pre-operative functional mucosal surface predict multiple organ dysfunction in patients undergoing elective cardiac surgery?
Observational (n=146)
Does reduced pre-operative functional mucosal surface predict multiple organ dysfunction in patients undergoing elective cardiac surgery?
A reduced pre-operative functional mucosal surface, indicated by lower absorbed mannitol, may predict the early occurrence of multiple organ dysfunction after cardiac surgery.
Answers are grounded in this paper and cite their sources.
Should not yet change pre-operative assessment; hypothesis-generating for mucosal function in post-cardiac surgery MODS risk.
We studied the influence of sequential involvement of the gastrointestinal (GI) tract on the development of multiple organ dysfunction (MOD) after cardiopulmonary bypass (CPB). One hundred and forty-six patients undergoing elective cardiac surgery were included in this prospective observational study. Standardized oral inert-sugar tests (sucrose, lactulose, mannitol, sucralose) were performed before and after CPB in different patients. Enzyme-linked immunosorbent assay of plasma levels of endotoxin core antibodies (EndoCAb) were performed peri-operatively. The functional mucosal surface was calculated from the amount of mannitol absorbed from the GI tract. Lower urine concentrations of absorbed mannitol were observed pre-operatively in patients developing MOD. In binary logistic regression this was an independent parameter. Decreased plasma concentrations of EndoCAb after surgery were seen in every patient, but were more significant in patients developing MOD. A reduced pre-operative functional mucosal surface may predict the early occurrence of MOD after surgery.
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Jp et al. (2007) conducted an observational in Multiple organ dysfunction after cardiopulmonary bypass (n=146). Reduced pre-operative functional mucosal surface was evaluated on Development of multiple organ dysfunction (MOD). A reduced pre-operative functional mucosal surface independently predicted the early occurrence of multiple organ dysfunction after cardiac surgery.
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