We have demonstrated the presence of both in vivo and in vitro antioxidant activities in the crude water-extract of the root of Polygonum multiflorum Thunb. (PMC), as indicated by its ability to protect against CCl4-induced hepatotoxicity in rats and to scavenge ferri-heme oxidants generated in an in vitro system. Activity-directed fractionation of the PMC indicated that the antioxidant components were contained in the ethylacetate fraction.
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Ip et al. (1997) studied this question.
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