Key result
Echovirus 11 infection was associated with a strong independent protective effect against IgE sensitization in children (OR 0.35; 95% CI 0.18-0.67; P=0.001).
Why the study?
Are enterovirus infections associated with protection against IgE sensitization in children?
Case-Control (n=250)
Are enterovirus infections associated with protection against IgE sensitization in children?
Odds Ratio: 0.35 (95% CI 0.18–0.67)
p-value: p=0.001
Infections by certain enterovirus types, particularly echovirus 11, are associated with protection against IgE sensitization in children.
Among other infectious agents, enteroviruses have been associated with protection against allergic diseases. The aim of the present study was to confirm these findings using a highly sensitive and specific neutralization antibody assay and to investigate whether the protective effect is related to certain enterovirus serotypes. Antibodies against 12 enterovirus serotypes were measured in 60 children who were positive for allergen-specific IgE and in 190 control children. Echoviruses seemed to be more protective than coxsackie-B-viruses and echovirus 11 had the strongest independent protective effect (P = 0.001; OR = 0.35, 95% CI: 0.18-0.67). The results support previous observations suggesting that infections by certain enterovirus types are associated with protection against IgE sensitization.
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Seiskari et al. (2011) conducted a case-control in IgE sensitization (n=250). Enterovirus infections (specifically echovirus 11) vs. Lack of infection or other enterovirus serotypes was evaluated on Allergen-specific IgE positivity (OR 0.35, 95% CI 0.18-0.67, p=0.001). Echovirus 11 infection was associated with a strong independent protective effect against IgE sensitization in children (OR 0.35; 95% CI 0.18-0.67; P=0.001).
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