Key result
Adolescent bariatric surgery was associated with a 53.5% prevalence of mild cognitive impairment at 10-year follow-up, with higher risk for Roux-en-Y gastric bypass and preoperative hypertension.
Why the study?
Although adult studies show improved postoperative cognitive function after bariatric surgery, little is known about the potential cognitive benefits of adolescent bariatric surgery, especially at extended follow-up.
Cohort (n=99)
Cognitive deficits and mild cognitive impairment are highly prevalent 10 years after adolescent bariatric surgery, particularly among those with preoperative hypertension or who underwent Roux-en-Y gastric bypass.
Answers are grounded in this paper and cite their sources.
May warrant long-term cognitive screening after adolescent bariatric surgery; leaves open causality and generalizability of procedure- and hypertension-related risks.
BACKGROUND: Adolescent bariatric surgery produces substantial weight loss and reduction of medical co-morbidities. Research in adult samples shows improved cognitive function postoperatively, although much less is known about the potential cognitive benefits of bariatric surgery in adolescents-especially at extended follow-up. OBJECTIVE: Examine cognitive function 10 years after adolescent bariatric surgery. SETTING: University hospital. METHODS: A total of 99 young adults who underwent bariatric surgery as adolescents completed a computerized cognitive test battery as part of a larger 10-year postoperative assessment. All had been long-term participants in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. RESULTS: Cognitive dysfunction was prevalent on tests of attention and executive function (e.g., Continuous Performance Test - Reaction Time 30%; Maze Errors - Overrun 30%), and 53.5% met research criteria for mild cognitive impairment (MCI). Modified Poisson regression with robust error variance revealed participants with preoperative hypertension and those completing Roux-en-Y gastric bypass were more likely to meet criteria for MCI at 10-year follow-up. CONCLUSIONS: The current findings indicate that cognitive deficits are common 10 years after bariatric surgery. Additional studies are needed to clarify possible cohort effects, determine whether these cognitive deficits persist to even later follow-up (e.g., 20 yr after surgery), and identify underlying mechanisms and mitigation strategies.
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Burke et al. (2024) conducted a cohort in Post-adolescent bariatric surgery (n=99). Adolescent bariatric surgery was evaluated on Mild cognitive impairment (MCI). Adolescent bariatric surgery was associated with a 53.5% prevalence of mild cognitive impairment at 10-year follow-up, with higher risk for Roux-en-Y gastric bypass and preoperative hypertension.
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