Key result
Subjects with antecedent poliomyelitis demonstrated no significant dysfunction of the peripheral autonomic nerves compared to age- and sex-matched controls.
Why the study?
Do subjects with antecedent poliomyelitis have altered autonomic cardiovascular responses compared to healthy controls?
Case-Control
Do subjects with antecedent poliomyelitis have altered autonomic cardiovascular responses compared to healthy controls?
Antecedent poliomyelitis is not associated with significant peripheral autonomic nerve dysfunction, suggesting no parallel deterioration with muscle atrophy.
Answers are grounded in this paper and cite their sources.
Antecedent poliomyelitis was not associated with peripheral autonomic dysfunction; leaves open whether cardiovascular responses differ in prospective studies.
Autonomically mediated cardiovascular responses were evaluated in 20 subjects with antecedent poliomyelitis and compared to data from an age- and sex-matched control group. The polio subjects had a lower heart rate response to the Valsalva manoeuvre but the same respiratory sinus arrhythmia as the controls. From this it is concluded that the polio subjects had a normal vagal function. The polio subjects had a greater initial heart rate increase but the same blood pressure response to the orthostatic position as the controls. This indicates a normal function of the sympathetic nerves. The greater heart rate increase is most likely caused by a displacement of blood to the legs because of muscle atrophy. The polio subjects had a smaller blood flow increase as an initial response to an isometric handgrip than the controls. This might be attributed to a reduced beta-adrenergic vasodilation, possibly due to a reduced central vasomotor drive. It is concluded that subjects with antecedent poliomyelitis have no significant dysfunction of the peripheral autonomic nerves. Thus, there is no deterioration of the peripheral autonomic nerve function in parallel with the progressive muscle atrophy and paralysis earlier described in post-polio subjects.
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Borg et al. (1988) conducted a case-control in Antecedent poliomyelitis. Antecedent poliomyelitis vs. Age- and sex-matched controls was evaluated on Autonomic cardiovascular responses (Valsalva manoeuvre, orthostatic position, isometric handgrip). Subjects with antecedent poliomyelitis demonstrated no significant dysfunction of the peripheral autonomic nerves compared to age- and sex-matched controls.
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