Key result
Primary lung cancer was associated with a significantly higher edema-mass ratio (p=0.001), while invasive ductal carcinoma of the breast had a lower ratio (1.95 vs 2.48, p=0.021).
Why the study?
The study was conducted to determine the relationship between the presence and amount of vasogenic edema and the origin, type, and grade of primary cancer in patients with brain metastases.
Does the presence and amount of vasogenic edema in brain metastasis differ according to the origin, type, and grade of primary cancer?
Cross-Sectional (n=292)
No
Does the presence and amount of vasogenic edema in brain metastasis differ according to the origin, type, and grade of primary cancer?
The amount and presence of vasogenic edema in brain metastases vary significantly depending on the primary tumor's origin and histological type, with higher edema-mass ratios seen in lung cancer.
Answers are grounded in this paper and cite their sources.
EMR differences by primary tumor may aid differential diagnosis of brain metastases; leaves open validation for prognostic or therapeutic utility.
OBJECTIVE: To determine the relationship of the presence and amount of vasogenic edema with origin, type, and grade of primary cancer. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Radiology Clinic, Ankara, Turkey, from July 2017 to October 2021. METHODOLOGY: Brain MRI scans of 292 patients were retrospectively evaluated. Age, gender, origin, type, and grade of primary cancer were determined. Metastasis type, and presence of vasogenic edema accompanying metastatic lesion were questioned. In cases of vasogenic edema accompanying metastatic lesions, the largest diameter of the vasogenic edema mass complex was measured in T2 sequences. In the contrast-enhanced series, the largest diameter of the metastatic lesion was measured, and the edema-mass ratio (EMR) was calculated by proportioning the diameter of the edema mass complex to the diameter of the mass. RESULTS: The frequency of vasogenic edema was found higher in patients with lung cancer compared to other primaries. The EMR was found statistically significantly higher in patients with primary lung cancer (p=0.001). This was particularly evident in the adenocarcinoma group. In the patient group with primary breast cancer, EMR was found significantly lower in patients with invasive ductal carcinoma. (IDC→1.95±0.66 vs. Other→2.48±0.52, Z=-2.301, p=0.021). CONCLUSION: The amount and presence of vasogenic edema in patients with brain metastases may differ according to the origin and type of primary tumour.
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Bilgin et al. (2022) conducted a cross-sectional in Brain metastasis (n=292). Primary cancer origin and type vs. Other primary cancer types was evaluated on Edema-mass ratio (EMR) (p=0.001). Primary lung cancer was associated with a significantly higher edema-mass ratio (p=0.001), while invasive ductal carcinoma of the breast had a lower ratio (1.95 vs 2.48, p=0.021).
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