Key result
Voluntary wheel running initiated at age 7 months for 3 months did not worsen skeletal or cardiac muscle function in mdx mice of either gender, and increased absolute maximal force in females.
Why the study?
Does voluntary wheel running affect skeletal and cardiac muscle function in adult mdx mice?
Does voluntary wheel running affect skeletal and cardiac muscle function in adult mdx mice?
Voluntary physical activity initiated in adult mdx mice does not have detrimental effects on skeletal or cardiac muscle function.
Supports safety of voluntary exercise in adult mdx mice; leaves open translation to human Duchenne muscular dystrophy.
INTRODUCTION: The effects of voluntary activity initiated in adult mdx (C57BL/10ScSc-DMD(mdx) /J) mice on skeletal and cardiac muscle function have not been studied extensively. METHODS: We studied the effects of 3 months of voluntary wheel running initiated at age 7 months on hindlimb muscle weakness, increased susceptibility to muscle contraction-induced injury, and left ventricular function in mdx mice. RESULTS: We found that voluntary wheel running did not worsen the deficit in force-generating capacity and the force drop after lengthening contractions in either mdx mouse gender. It increased the absolute maximal force of skeletal muscle in female mdx mice. Moreover, it did not affect left ventricular function, structural heart dimensions, cardiac gene expression of inflammation, fibrosis, or remodeling markers. CONCLUSION: These results indicate that voluntary activity initiated at age 7 months had no detrimental effects on skeletal or cardiac muscles in either mdx mouse gender.
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Ferry et al. (2015) studied mdx mice (Duchenne muscular dystrophy model). Voluntary wheel running was evaluated on Skeletal hindlimb and cardiac muscle function. Voluntary wheel running initiated at age 7 months for 3 months did not worsen skeletal or cardiac muscle function in mdx mice of either gender, and increased absolute maximal force in females.
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