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A remarkable progress has been made in the treatment of the rickettsial diseases since 1945. For example para-aminobenzoic acid (PABA) was found to be of therapeutic value in 1945. The more powerful antibiotics, Chloromycetin, Aureomycin and terramycin were found one after another against rickettsia. Now rickettsial disease no more belongs to a terrible disease if treated properly with those antibiotics. In 1948 we had an opportunity to treat the scrub typhus cases in Niigata and good results had been obtained. In the next year compared to the results with PABA the oral administ-ration of Chloromycetin were observed in the scrub typhus cases.
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KITAOKA et al. (1950) studied this question.
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