All articles of this category The scope of Zincke's synthesis of pyridinium salts using various chiral primary amines and mono- or dialkylpyridines substituted at positions 3, 4 or 5 has been investigated. Salts 6a-f , 9a-i , and 10b,e,h-j were obtained in excellent yields. The results support the accepted mechanism for Zincke's reaction and shows the influence of the solvent on the course of this reaction.
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Génisson et al. (1992) studied this question.