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July 27, 2006Neurogastroenterology & Motility

Vasoactive intestinal peptide receptor subtypes and signalling pathways involved in relaxation of human stomach

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Key result

Vasoactive intestinal peptide caused greater relaxation of smooth muscle cells in the human antrum (ED50 0.53 nmol/L) compared to the fundus (ED50 3.4 nmol/L) due to distinct myogenic properties.

Population

Human stomach smooth muscle cells (SMC) and strips of the fundus and antrum

Design

Preclinical

Authors

CSCarola SeveriSapienza University of RomeITIvan TattoliSapienza University of RomeVCVito D. CorletoUniversity of Rome Tor Vergata

Discussion

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Implication

Regional VIP responsiveness in human stomach warrants targeted motility studies; leaves open clinical translation from isolated cells.

Structured PICO

P
Population
Human stomach smooth muscle cells (SMC) and strips of the fundus and antrum
I
Intervention
Vasoactive intestinal peptide (VIP) and various pathway activators/inhibitors (forskolin, 2'5'-dideoxyadenosine, Rp-cAMPs, sodium nitroprusside, LY83583, KT5823)
O
Outcome
Relaxation of smooth muscle cells and strips, receptor expression, and signalling pathway activationsurrogate

Regional differences in VIP action on the human stomach are related to distinct myogenic properties of smooth muscle cells in the antrum and fundus.

Cite This Study

Severi et al. (2006) studied this question. Vasoactive intestinal peptide (VIP) was evaluated on Relaxation of smooth muscle cells and strips. Vasoactive intestinal peptide caused greater relaxation of smooth muscle cells in the human antrum (ED50 0.53 nmol/L) compared to the fundus (ED50 3.4 nmol/L) due to distinct myogenic properties.

synapsesocial.com/papers/6a95af97ffc709ce7ffce000https://doi.org/10.1111/j.1365-2982.2006.00822.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Activation of distinct cAMP- and cGMP-dependent pathways by relaxant agents in isolated gastric muscle cells1993 · 80 citations
  2. 2Differential gene expression of the three natriuretic peptides and natriuretic peptide receptor subtypes in human liver.1997 · 39 citations
  3. 3The inhibitory effects of vasoactive intestinal polypeptide on the mechanical and electrical activity of canine antral smooth muscle.1978 · 89 citations
  4. 4Parallel pathways mediate inhibitory effects of vasoactive intestinal polypeptide and nitric oxide in canine fundus1999 · 36 citations