Solid‐state NMR spectroscopy is used to determine the structures of membrane peptides and proteins in lipid bilayers. The methodology for membrane protein structure determination using solid‐state NMR of oriented lipid bilayer samples is outlined. Recent developments in recombinant bacterial expression systems for the preparation of isotopically labeled membrane proteins, pulse sequences for high‐resolution spectroscopy, and structural indices that guide the structure assembly process greatly extend the capabilities of the technique.
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Francesca M. Marassi (2002) studied this question.
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