Key result
Among 154 Iranian patients with ischemic heart disease, the prevalence of CYP2C19 *1 (normal), *2 (heterozygote), and *3 (homozygote) genotypes was 72.7%, 23.4%, and 3.9%, respectively.
Cross-Sectional (n=154)
No
In Iranian patients with ischemic heart disease, the prevalence of CYP2C19 loss-of-function alleles (*2 and *3) is approximately 27.3%, suggesting a significant portion may be poor or intermediate metabolizers of clopidogrel.
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Suggests clopidogrel metabolism variability in Iranian IHD patients; leaves open prospective genotyping-outcome studies.
Background: Clopidogrel is a standout amongst the most ordinarily recommended medications to avoid ischemic occasions taking after coronary disorder or stant position. However, impaired responses the therapy as well as resistance to the therapy have also been reported. Genetic variants play an important role in clopidogrel biotransformation of its active metabolite that may subsequently influence the antiplatelet effect of clopidogrel. The objective of this study was to evaluate the prevalence of the cytochrome P450 (CYP450) 2C19 enzyme (CYP2C19) genotypes which are involved in the activation of clopidogrel in a random Iranian population of various ethnic groups (Persian, Azari, Kurd, etc.). Molecular analysis of CYP2C19 polymorphisms may be helpful in the determination of optimal antiplatelet therapy. Materials and Methods: CYP2C19 (*1/*2/*3) variants were assessed by Polymerase Chain Reaction-Restriction Length Polymorphism (PCR-RFLP) assays in a representative sample of 154 Iranian patients with ischemic heart disease.
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Poopak et al. (2016) conducted a cross-sectional in Ischemic heart disease (n=154). CYP2C19 *2 and *3 alleles vs. CYP2C19 *1 (normal genotype) was evaluated on Prevalence of CYP2C19 genotypes. Among 154 Iranian patients with ischemic heart disease, the prevalence of CYP2C19 *1 (normal), *2 (heterozygote), and *3 (homozygote) genotypes was 72.7%, 23.4%, and 3.9%, respectively.
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