Recent update on barbiturate in relation to brain disorder

Barbiturate is a potent substance which forms a quintessential part of the NDPS Act.The substance is categorized under the psychoactive groups of drugs and is essentially a drug that possesses both hypnotic and sedative properties.The precursor for barbiturate is barbituric acid which is a condensation product of malonic acid and urea.However, barbituric acid itself is not a centrally acting depressant.Diethylbarbituric acid (Veronal) is the first ever barbiturate with hypnotic properties that was used as early as 1903 (Hadjihambi et al., 2020).The drug induced sleep both in human and animals.The substance was also called as barbital.Later in the year 1912, a second barbiturate drug, phenobarbitone was introduced into clinical practice which had both sedative and hypnotic properties.The phenomenal success of both these drugs announced the beginning of the barbiturate era.Their influence as the pre-eminent sedative-hypnotic agents was felt for over half a century.Although several so-called non-barbiturate drugs attempted to displace the barbiturates from their pinnacle from time to time, it was not until 1961 when a substance named chlordiazepoxide was introduced into the market that their position was seriously challenged (Velle et al., 2021).Several earlier studies have reported the characteristic features and the severity of the barbiturate withdrawal syndrome.In cases of mild withdrawal syndrome, symptoms like apprehension, hyperexcitability, mild tremors, loss of appetite and piloerection were observed.