Biophysical studies on bone tissue.VI. Biophysical studies on bone tissue from osteogenic sarcoma

STEOGENIC SARCOMAS are the most common 0 of the various types of primary malignant bone tumors. They occur especially in children and young people and have a maximal frequency in the age group between 10 and 25 years. These tumors have a very malignant course, and even after early radical surgical treatment a five years' survival is not expected in niore than about 10 per cent of the cases. The long bones are the common site for these tumors; usually the end of the shaft is involved and the lesions are thus generally localized to the growth zones of these bones. Osteogenic sarcomas are composed of a tissue with bone-forming properties and they vary much in appearance: some are sclerotic, forming an abundance of new bone tissue, while in others the osteolytic processes are predominant. As regards cellularity and cell pleomorphism there are great variations, not only between different tumors but also between different parts of the same tumor.61 7