A Concise Total Synthesis of (±)‐Vigulariol

From the deep: Vigulariol has been efficiently synthesized in 20 steps and 4.0 % overall yield from commercially available starting materials. Key to the synthesis was the use of copper(II) hexafluoroacetylacetate [Cu(hfacac)2] to form the oxabicyclo[6.2.1]undecene system (see scheme; TBS=tert-butyldimethylsilyl). The strategy should provide access to other members of the cladiellin family.