Key result
For each additional month of ambulation by an older brother with Duchenne or Becker muscular dystrophy, the hazard of ceased ambulation by his younger brother decreased by 4%.
Observational (n=120)
Yes
Hazard Ratio: 0.96
p-value: p=<0.001
While the age of ceased ambulation in older brothers with Duchenne or Becker muscular dystrophy predicts the timeline for their younger brothers, the onset of scoliosis and cardiomyopathy varies widely between siblings.
May aid familial counseling on ambulation in Duchenne/Becker muscular dystrophy; leaves open prediction of scoliosis or cardiomyopathy.
INTRODUCTION: The correlation of markers of disease severity among brothers with Duchenne or Becker muscular dystrophy has implications for clinical guidance and clinical trials. METHODS: Sibling pairs with Duchenne or Becker muscular dystrophy (n = 60) were compared for ages when they reached clinical milestones of disease progression, including ceased ambulation, scoliosis of ≥ 20°, and development of cardiomyopathy. RESULTS: The median age at which younger brothers reached each milestone, compared with their older brothers ranged from 25 months younger for development of cardiomyopathy to 2 months older for ceased ambulation. For each additional month of ambulation by the older brother, the hazard of ceased ambulation by the younger brother decreased by 4%. CONCLUSIONS: The ages when siblings reach clinical milestones of disease vary widely between siblings. However, the time to ceased ambulation for older brothers predicts the time to ceased ambulation for their younger brothers.
No takes yet. Share an insight, caveat, or question.
Pettygrove et al. (2013) conducted an observational in Duchenne and Becker muscular dystrophies (n=120). Older brother's age at ceased ambulation was evaluated on Age at which younger brothers reached ceased ambulation (HR 0.96, p=<0.001). For each additional month of ambulation by an older brother with Duchenne or Becker muscular dystrophy, the hazard of ceased ambulation by his younger brother decreased by 4%.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: