Why the study?
Does a uniform lyophilized 'normal' plasma provide comparable reliability to the mean normal prothrombin time (MNPT) of fresh plasmas for prothrombin ratio determination?
Population
37 international centres performing prothrombin ratio determination
Comparison
Uniform lyophilized 'normal' plasma vs Mean normal prothrombin time based on fresh…
Design
Other
Authors
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Lyophilized normal plasma may substitute for MNPT in ISI calibration; leaves open whether it simplifies INR standardization in routine practice.
Does a uniform lyophilized 'normal' plasma provide comparable reliability to the mean normal prothrombin time (MNPT) of fresh plasmas for prothrombin ratio determination?
A uniform lyophilized 'normal' plasma can be reliably substituted for the mean normal prothrombin time of fresh plasmas for ISI calibration, simplifying standardization across centers.
Poller et al. (1994) studied this question.
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