A combination of fluorescence spectroscopy and dynamic laser light scattering is used to investigate the relationship between the extent of hybridization on the surface of DNA-functionalized gold nanoparticles and the hydrodynamic radius (Rh) of the nanoparticle. The hydrodynamic radius of the DNA-Au conjugate increases measurably only after approximately 5-10 DNA hybridization events and saturates at its maximum value well before the surface is fully loaded.
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Xu et al. (2007) studied this question.
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