Interleukin-2 and the Chronic Fatigue Syndrome

Letters and Corrections15 February 1989Interleukin-2 and the Chronic Fatigue SyndromePaul R. Cheney, MD, PhD, Susan E. Dorman, David S. Bell, MDPaul R. Cheney, MD, PhDSearch for more papers by this author, Susan E. DormanSearch for more papers by this author, David S. Bell, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-4-321_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The chronic fatigue syndrome (the chronic mononucleosis syndrome, the chronic Epstein-Barr virus syndrome) is a recently described illness with numerous symptoms of unknown cause (1, 2). Abnormalities of natural killer function and decreased enhancement of cytotoxicity in the presence of interleukin-2 have been found (3). The results of recent studies (4) of cancer treatment with recombinant interleukin-2 alone and in combination with autologous lymphokine-activated killer cells have documented side effects that superficially resemble manifestations of the chronic fatigue syndrome. For this reason, we undertook a preliminary study of interleukin-2 plasma levels in two geographically separate groups of...References1. Straus S. The chronic mononucleosis syndrome. J Infect Dis. 1988;157:405-12. CrossrefMedlineGoogle Scholar2. Komaroff A. The "chronic mononucleosis" syndromes. Hosp Pract. 1987;22:71-5. MedlineGoogle Scholar3. CaligiuriMurrayBuchwald MCD. Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome. J Immunol. 1987;139:3306-13. MedlineGoogle Scholar4. DenicoffRubinowPapa KDM. The neuropsychiatric effects of treatment with interleukin-2 and lymphokine-activated killer cells. Ann Intern Med. 1987;107:293-300. LinkGoogle Scholar5. HolmesKaplanGantz GJN. Chronic fatigue syndrome: a working case definition. Ann Intern Med. 1988;108:387-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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