Objective To examine whether long‐term consumption of a probiotic milk could reduce gastrointestinal and respiratory infections in children in day care centres. Design Randomised, double blind, placebo controlled study over 7 months. Setting Eighteen day care centres in Helsinki, Finland. Participants A total of 571 healthy children aged 1–6 years: 282 [mean (SD) age 4.6 (1.5) years] in the intervention group and 289 [mean (SD) age 4.4 (1.5) years] in the control group. Intervention Milk with or without Lactobacillus GG. Average daily consumption of milk in both groups was 260 mL. Main outcome measures Number of days with respiratory and gastrointestinal symptoms, absences from day care because of illness, respiratory tract infections diagnosed by a doctor, and course of antibiotics. Results Children in the Lactobacillus group had fewer days of absence from day care because of illness [4.9 (95% confidence interval 4.4–5.5) versus 5.8 (5.3–6.4) days, 16% difference, p = 0.03; age adjusted 5.1 (4.6–5.6) versus 5.7 (5.2–6.3) days, 11% difference, p = 0.09]. There was also a relative reduction of 17% in the number of children suffering from respiratory infections with complications and lower respiratory tract infections [unadjusted absolute percentage reduction 8.6 (17.2–0.1), p = 0.05; age adjusted odds ratio 0.75 (0.52–1.09), p = 0.13] and a 19% relative reduction in antibiotic treatments for respiratory infection [unadjusted absolute percentage reduction 9.6 (18.2–1.0), p = 0.03; adjusted odds ratio 0.72 (0.50–1.03), p = 0.08] in the Lactobacillus group. Conclusions Lactobacillus GG may reduce respiratory infections and their severity among children in day care. The effects of the probiotic Lactobacillus GG were modest but consistently in the same direction.
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Richard Reading (2001) studied this question.