Virus sequence data are an essential resource for reconstructing spatiotemporal dynamics of viral spread as well as to inform treatment and prevention strategies. However, the potential benefit for these applications critically depends on accurate and correctly annotated alignments of genetically heterogeneous data. VIRULIGN was built for fast codoncorrect alignments of large datasets, with standardized genome annotation and various alignment export formats. VIRULIGN is freely available at https://github.com/rega-cev/virulign as an open source software project.
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Libin et al. (2018) studied this question.
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