A Facile and Efficient Solid Supported, One-Pot Synthesis of Functionalized Piperidine Derivatives Catalyzed by Amberlite IRA400-Cl Resin/I2/KI via Multicomponent Reaction

A facile and efficient one-pot, solid supported synthesis of functionalized piperidine derivatives catalyzed by Amberlite IRA400-Cl resin/I2/KI via a multicomponent reaction of various aldehydes, aromatic amines, and 1,3-dicarbonyl compounds has been achieved. The reaction has been carried out in a one-pot reaction and Amberlite resin as a solid supported catalyst at room temperature. Shorter reaction time, easy workup, yield, and mild reaction condition make the novel synthetic strategy both practical and attractive.