Key result
Acquired coronary artery disease was identified in 1.3% (17 of 1,345) of adult patients with congenital heart disease, presenting between 35 and 70 years of age in the presence of traditional cardiovascular risk factors.
Why the study?
Acquired coronary artery disease is increasingly recognized in the growing and ageing population of adults with congenital heart disease, but clinical experience and treatment issues needed to be characterized.
Observational (n=1,345)
No
Answers are grounded in this paper and cite their sources.
Acquired coronary artery disease is an increasingly recognized complication in aging adults with congenital heart disease, necessitating appropriate screening and revascularization strategies.
Objective: Acquired coronary artery disease, initially thought to rarely affect survivors of congenital heart disease, is increasingly recognized in this population, as these patients grow in age and numbers in the recent era. This study reports our experience with coronary artery disease in adults with congenital heart disease and discusses treatment issues and the existing literature. Methods: Retrospective review of all charts of adults with congenital heart disease and acquired coronary artery disease was performed. Patients’ clinical characteristics, diagnosis, risk factors, noninvasive and invasive imaging and management data were recorded. Results: Coronary artery disease was diagnosed at 35–70 of age in 17 patients out of a total of 1345 adult congenital heart disease patients followed. Congenital heart disease was moderate or complex in 5 patients (4 repaired Tetralogy of Fallot, 1 repaired ventricular septal defect) and simple unrepaired atrial septal defect diagnosed later in life before or after coronary artery disease identi- fication in 12 patients. Coronary artery disease symptoms were present in 12 patients (8 myocardial infarctions, 4 exercise intolerance), while all patients had 2–3 risk factors for coronary artery disease. Coronary angiography showed 1–3 vessel disease treated with percutaneous coronary intervention in 7 patients, coronary artery bypass graft in 2 patients and both in 2 patients. Patients received appropriate medical therapy and remained stable for 1–17 years, while 2 patients are awaiting surgical pulmonary valve replacement in the near future. Conclusion: Coronary artery disease can develop in adults with congenital heart disease later in life in the presence of traditional risk factors, and prevention, screening and treatment strategies should be applied in this population. Further studies are needed to fully elucidate the extent of this issue in this increasing and ageing population and to determine its optimal medical, interventional and surgical management.
No takes yet. Share an insight, caveat, or question.
Apostolopoulou et al. (2020) conducted an observational in Congenital heart disease and acquired coronary artery disease (n=1,345). Acquired coronary artery disease was evaluated on Diagnosis of acquired coronary artery disease. Acquired coronary artery disease was identified in 1.3% (17 of 1,345) of adult patients with congenital heart disease, presenting between 35 and 70 years of age in the presence of traditional cardiovascular risk factors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: