A soluble specific antigen, which occurs in tissues of animals infected with the virus of lymphocytic choriomeningitis, fixes complement in the presence of immune serum; the virus freed from the soluble antigen fixes complement poorly or not at all. Patients recovered from lymphocytic choriomeningitis develop in their serum antibodies that react with the soluble antigen to fix complement.
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Smadel et al. (1939) studied this question.
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