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Embryonic rat tooth germs were treated with 5-bromodeoxyuridine in vitro. Morphodifferentiation and histodifferentiation were arrested. Epithelial and mesenchymal deoxyribonucleic acid and protein synthesis were unaffected, whereas ribonucleic acid and collagen synthesis were retarded in the mesenchyme only. Inhibition of odontogenesis by this agent appears to be tissue-specific.
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Schwartz et al. (1974) studied this question.
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