Key result
Photo-oxidation of porcine stentless valves significantly reduced aortic wall calcium content compared to glutaraldehyde-fixed valves (0.71 vs 10.78; P < 0.05).
Why the study?
Does photo-oxidation prevent aortic wall calcification in porcine stentless bioprostheses compared to glutaraldehyde fixation in juvenile sheep?
Does photo-oxidation prevent aortic wall calcification in porcine stentless bioprostheses compared to glutaraldehyde fixation in juvenile sheep?
Photo-oxidation of porcine stentless valves prevents calcification in the aortic wall portion compared to standard glutaraldehyde fixation in a juvenile sheep model.
Answers are grounded in this paper and cite their sources.
Caution against clinical adoption in bioprostheses; hypothesis-generating for durability and requires human trials.
PURPOSE: Aortic wall calcification is problematic in stentless porcine valves. We evaluated the possible anticalcification effect of photo-oxidation on the aortic wall portion of porcine stentless bioprostheses. A comparison with glutaraldehyde-fixed tissue was made. METHODS: Six Photofix and six Freestyle valves were implanted in juvenile sheep in pulmonary position. Valves were explanted after 3 or 6 months and examined macroscopically, by x-ray, light, and transmission electron microscopy. Calcium content was determined by atomic absorption spectrometry. RESULTS: The aortic wall portion of all Photofix valves remained free from calcification, while the wall portion of glutaraldehyde-fixed valves calcified strongly, both after 3 and 6 months. Calcium content of the aortic wall portion was: 0.71 +/- 1.27 in the Photofix valves versus 10.78 +/- 77.22 in the Freestyle valves (P < 0.05). CONCLUSION: Photo-oxidation of a porcine stentless valve prevents calcification not only in the cusps but also in the aortic wall portion.
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Meuris et al. (2003) studied Aortic wall calcification (n=12). Photofix valves (dye-mediated photo-oxidation) vs. Freestyle valves (glutaraldehyde-fixed) was evaluated on Calcium content of the aortic wall portion (p=< 0.05). Photo-oxidation of porcine stentless valves significantly reduced aortic wall calcium content compared to glutaraldehyde-fixed valves (0.71 vs 10.78; P < 0.05).
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