Key result
A PA E23K mutant influenza A(H1N1)pdm09 virus with reduced baloxavir susceptibility and growth capability was detected in an untreated child, suggesting possible human-to-human transmission.
Why the study?
Human-to-human transmission of PA I38 mutant influenza A(H3N2) viruses with reduced baloxavir susceptibility had been reported in Japan, prompting surveillance.
Case Report (n=1)
Detection of a baloxavir-resistant influenza A(H1N1)pdm09 mutant in an untreated patient highlights the potential for human-to-human transmission of resistant strains and the need for ongoing surveillance.
This is the authors' abstract. We don't add key points for this paper.
Human-to-human transmission of PA I38 mutant influenza A(H3N2) viruses with reduced baloxavir susceptibility has been reported in Japan. In December 2019, we detected a PA E23K mutant A(H1N1)pdm09 virus from a child without baloxavir treatment. The PA E23K mutant virus exhibited reduced baloxavir susceptibility but remained susceptible to neuraminidase inhibitors. Epidemiological data suggest possible transmission of this PA E23K mutant virus among humans, although its growth capability relative to that of the wild-type virus was reduced. Therefore, baloxavir susceptibility monitoring of influenza viruses is essential.
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May signal community transmission risk of baloxavir-resistant strains; leaves open need for expanded influenza antiviral surveillance.
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Takashita et al. (2020) conducted a case report in Influenza A(H1N1)pdm09 (n=1). PA E23K mutant A(H1N1)pdm09 virus vs. Wild-type virus was evaluated on Baloxavir susceptibility and growth capability. A PA E23K mutant influenza A(H1N1)pdm09 virus with reduced baloxavir susceptibility and growth capability was detected in an untreated child, suggesting possible human-to-human transmission.
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