This study demonstrates that differentiating fetal-mouse muscle cells, specifically myoblastic elements, can support the replication of Group A coxsackieviruses, contrary to previous findings that mouse cell cultures were restrictive.
Should not yet influence clinical management of viral myocarditis; leaves open myoblast cultures as tools for mechanistic studies.
Differentiating primary fetal-mouse muscle-cell cultures have been shown to support the replication of prototype strains of coxsackieviruses A1 and A5. Heretofore, mouse cell cultures had been found to be restrictive to the growth of these agents. Myoblastic elements rather than fibroblasts appeared to be the primary cell type susceptible to infection by those coxsackieviruses of Group A tested.
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Landau et al. (1972) studied this question.
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