Key result
Rheumatoid arthritis was associated with a significantly higher prevalence of coronary artery disease compared to matched controls without the condition (OR 2.97).
Why the study?
Previous studies linking rheumatoid arthritis and coronary artery disease were primarily conducted in non-Asian populations, leaving their relationship in South Korea unclear.
Does rheumatoid arthritis increase the prevalence of coronary artery disease in the Korean population?
Cross-Sectional (n=25,828)
Does rheumatoid arthritis increase the prevalence of coronary artery disease in the Korean population?
Rheumatoid arthritis is associated with a nearly three-fold increased odds of prevalent coronary artery disease in the Korean population, independent of traditional cardiovascular risk factors.
Answers are grounded in this paper and cite their sources.
May support CAD vigilance in Korean RA patients; leaves open causality and prospective confirmation.
BACKGROUND: Rheumatoid arthritis (RA) is known to be associated with coronary artery diseases (CAD). Previous studies of the association between RA and CAD were reported mainly in non-Asian groups. We aimed to examine the prevalence of RA and the relationship between RA and CAD in South Korea. METHODS: We conducted a nationwide cross-sectional study by using the Korea National Health and Nutrition Examination Survey, which collected data for four years between 2008 and 2012. A total of 25,828 eligible participants were included. To balance the distribution of baseline characteristics, we used propensity score-matching. A multivariable logistic regression model was employed and we calculated the odds ratios (ORs) and 95% confidence intervals (CI) for the odds of the participants with RA on CAD prevalence. RESULTS: The prevalence of RA in Korea from 2008 to 2012 was 0.6% and RA was predominant among elderly women. The prevalence of CAD in patients with RA was significantly higher than in general population. After propensity score-matching to balance the confounding factors, RA was significantly associated with CAD (OR 2.97, 95% CI 1.15-7.68, P = 0.02). CONCLUSIONS: The prevalence of RA in South Korea was comparable to the worldwide data, and the presence of CAD in RA patients was more than two-fold.
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Lee et al. (2019) conducted a cross-sectional in Rheumatoid arthritis and coronary artery disease (n=25,828). Rheumatoid arthritis vs. Participants without rheumatoid arthritis was evaluated on Prevalence of coronary artery disease (OR 2.97, 95% CI 1.15-7.68, p=0.02). Rheumatoid arthritis was associated with a significantly higher prevalence of coronary artery disease compared to matched controls without the condition (OR 2.97).
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