Key result
Adiponectin/BMI was significantly and independently inversely correlated with mean blood pressure in premenopausal women (β = -0.383, P<0.001), but not in postmenopausal women.
Why the study?
Does the relationship between adiponectin and blood pressure differ between premenopausal and postmenopausal women?
Cross-Sectional (n=262)
Does the relationship between adiponectin and blood pressure differ between premenopausal and postmenopausal women?
The inverse relationship between adiponectin and blood pressure is present in premenopausal women but appears to be lost after menopause.
Answers are grounded in this paper and cite their sources.
Supports menopause-specific inverse adiponectin-BP link; hypothesis-generating and requires prospective validation before clinical consideration.
PURPOSE: Menopause can affect the reportedly inverse association between adiponectin and blood pressure (BP); however, this relationship is still poorly understood. The present study cross-sectionally compared the relationship between adiponectin and BP in pre- and postmenopausal women. METHODS: Healthy, asymptomatic women on no medication (n = 262) were divided into a premenopausal group (n = 125, mean age 44.7 years) and a postmenopausal group (n = 137, mean age 65.6 years). Fasting values of serum adiponectin and BP were measured, in addition to body mass index (BMI), blood glucose and lipids. The correlation between the levels of adiponectin/BMI and mean BP (MBP) was analyzed with a linear regression model for the respective groups. RESULTS: The median adiponectin/BMI did not significantly differ between the pre- and postmenopausal groups (0.37 and 0.42, P = 0.08), and the premenopausal group had a significantly lower level of mean MBP than the postmenopausal group (87.6 and 100.7 mmHg, P < 0.001). In an unadjusted analysis, adiponectin/BMI was found to be significantly and inversely correlated with MBP in the premenopausal group (r = -0.499, P < 0.001) and the postmenopausal group (r = -0.203, P < 0.01), respectively. In a stepwise multivariate-adjusted analysis, adiponectin/BMI remained significantly, inversely and independently correlated with MBP in the premenopausal group (β = -0.383, P < 0.001), while no significant correlation was found between adiponectin/BMI and MBP for the postmenopausal group. CONCLUSIONS: The adiponectin-BP relationship appears to be associated with premenopausal state.
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Kotani et al. (2011) conducted a cross-sectional in Healthy, asymptomatic women (n=262). Adiponectin/BMI was evaluated on Mean blood pressure (MBP) (β = -0.383, p=<0.001). Adiponectin/BMI was significantly and independently inversely correlated with mean blood pressure in premenopausal women (β = -0.383, P<0.001), but not in postmenopausal women.
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