Regulation of the cytoplasmic pH of Exiguobacterium aurantiacum is dependent on the presence of Na+ in the medium. The data suggest that above 500 μM external Na+ the cells are able to regulate the cytoplasmic pH by the operation of a Na+ cycle involving a Na+/H+ antiport and a route for rapid Na+ entry. Our data indicate that the rate of entry of Na+ is subject to control by the cytoplasmic pH via feedback inhibition.
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McLaggan et al. (1984) studied this question.
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