Key result
Lignocaine 10 mg given prior to or mixed with methohexitone significantly reduced reported pain on injection from 49% to 20% and 23% respectively (p<0.05).
Why the study?
Does lignocaine reduce pain on injection of methohexitone in depressed patients undergoing electroconvulsive therapy?
Does lignocaine reduce pain on injection of methohexitone in depressed patients undergoing electroconvulsive therapy?
Lignocaine 10 mg administered prior to or mixed with methohexitone significantly reduces injection pain without affecting seizure duration during electroconvulsive therapy.
May reduce methohexitone injection pain in ECT; hypothesis-generating and requires randomized confirmation before practice change.
The present study was designed to assess the incidence of pain when methohexitone was administered to 35 depressed patients who had electroconvulsive therapy, and to determine whether the use of lignocaine could modify this, without affecting seizure duration. The same patients were studied during three separate treatment sessions; they received either methohexitone alone or mixed with, or preceded by, lignocaine 10 mg. Six (17%) patients spontaneously complained of pain during injection of methohexitone alone; the use of lignocaine prior to methohexitone reduced this to zero (p less than 0.05). A total of 49% patients reported pain during injection of methohexitone; the use of lignocaine either mixed with, or given prior to, methohexitone significantly reduced this to 23% and 20% respectively (p less than 0.05). Seizure duration was not significantly different during the three treatments.
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Simpson et al. (1989) studied Depression requiring electroconvulsive therapy (n=35). Lignocaine vs. Methohexitone alone was evaluated on Reported pain during injection (p=<0.05). Lignocaine 10 mg given prior to or mixed with methohexitone significantly reduced reported pain on injection from 49% to 20% and 23% respectively (p<0.05).
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