Key result
Pomegranate juice intake in diabetic rats significantly decreased retinal 8OHdG (P=0.004) and MDA (P<0.001) levels and increased GSH and GSH-Px activities compared to untreated diabetic rats.
Why the study?
Does pomegranate juice intake reduce retinal oxidative stress in streptozotocin-induced diabetic rats?
Does pomegranate juice intake reduce retinal oxidative stress in streptozotocin-induced diabetic rats?
p-value: P=0.004, P<0.001
Pomegranate juice intake reduces oxidative stress markers and increases antioxidant enzyme activities in the retinas of diabetic rats.
May attenuate retinal oxidative stress in diabetic rat models; leaves open translation to human diabetic retinopathy.
AIM: To investigate the effect of pomegranate juice (PJ) intake on overall oxidation status in retinas of diabetic rats. METHODS: Twenty-seven rats were divided into four groups as control (CO), diabetic (DM), control treated with PJ (CO-PJ), and diabetic treated with PJ (DM-PJ).The retina tissues were used to determine 8-hydroxy-2’-deoxyguanosine (8OHdG), malondialdehyde (MDA), reduced glutathione (GSH) levels, and the enzyme activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). RESULTS: The levels of 8OHdG and MDA were significantly increased in the retina of DM group compared to CO group (P=0.001, P<0.001 respectively). Both 8OHdG and MDA levels were decreased in PJ-DM group compared to DM group (P=0.004, P<0.001 respectively). The activities of antioxidant enzymes GSH, SOD, and GDH-Px were significantly decreased in the retina of DM group compared to CO group (P≤0.01). GSH and GSH-Px activities were higher in PJ-DM group compared with DM group (P=0.010, P=0.042, respectively) but SOD activity was not statistically different (P=0.938). CONCLUSION: PJ intake is found to be effective in decreasing oxidative end products, and in increasing the activities of antioxidant enzymes in diabetic retinas of rats, which suggests it may be effective against oxidative stress in diabetic retinas.
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Tuğcu et al. (2017) studied Streptozotocin-induced diabetes (n=27). Pomegranate juice vs. No pomegranate juice was evaluated on Overall oxidation status in retinas (8OHdG, MDA, GSH levels, and SOD and GSH-Px activities) (p=P=0.004, P<0.001). Pomegranate juice intake in diabetic rats significantly decreased retinal 8OHdG (P=0.004) and MDA (P<0.001) levels and increased GSH and GSH-Px activities compared to untreated diabetic rats.
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