Meta‐C−H functionalization of benzylamines has been developed using a PdII/transient mediator strategy. Using 2‐pyridone ligands and 2‐carbomethoxynorbornene (NBE‐CO2Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized. This protocol features a broad substrate scope and is compatible with heterocylic coupling partners. Moreover, the loading of the Pd can be lowered to 2.5 mol % by using the optimal ligand.
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Wang et al. (2017) studied this question.
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