Key result
Circadian rhythms of high-sensitivity cardiac troponin T, with peak morning concentrations that decrease during the day, may significantly impact the accuracy of early diagnostic algorithms for acute myocardial infarction.
Why the study?
Recent studies reported circadian rhythms in cardiac troponins, raising the need to consider additional factors affecting serum concentrations when interpreting sensitive early diagnostic algorithms for acute myocardial infarction.
Circadian variations in hs-cTnT levels, peaking in the morning, could potentially lead to false-positive diagnoses of acute myocardial infarction when using rapid 1-hour or 3-hour algorithms.
Methods for the determination of cardiac troponins have been significantly improved, facilitating further advancement of the therapeutic and diagnostic process of the cardiovascular diseases case management. In particular, acceleration of the acute myocardial infarction testing (early diagnostic algorithms: 0-1 h, 0-3 h) enabled earlier detection and choice of the optimal treatment tactics. At the same time, with the increased sensitivity in the laboratory test results interpretation, there emerged a necessity to take into account some additional factors that may affect the concentration of cardiac troponins in blood serum. Several recent studies have reported the existence of circadian rhythms in cardiac troponins. This article aims to discuss the possible mechanisms of how circadian rhythms of cardiac troponins develop and their influence on the diagnosis of acute myocardial infarction.
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A 2021 study conducted a review in Acute myocardial infarction. Circadian rhythms of cardiac troponins was evaluated. Circadian rhythms of high-sensitivity cardiac troponin T, with peak morning concentrations that decrease during the day, may significantly impact the accuracy of early diagnostic algorithms for acute myocardial infarction.
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