Thyrocalcitonin was given to rats 2.5 hr after injecting 45Ca intravenously. The normal continuous fall in specific activity of blood calcium was interrupted by the action of thyrocalcitonin but there was no effect on the disappearance of radiocalcium from the circulation even though serum Ca fell 30–50%. The data were analyzed with a computer program encompassing a model for calcium exchange with compartments arranged in series. The model adequately reproduced the experimental results which led to the conclusion that thyrocalcitonin acts by inhibiting resorption of calcium from bone. (Endocrinology82: 377, 1968)
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O’Riordan et al. (1968) studied this question.