Why the study?
The study examined procedures aimed at preserving the left ventricle during mitral valve prosthesis in operative correction of combined mitral-aortal failure.
Does preservation of mitral subvalvular structures improve left ventricular morphometric indices in patients with combined mitral-aortic failure and left-sided ventriculomegaly?
Cohort (n=340)
No
Does preservation of mitral subvalvular structures improve left ventricular morphometric indices in patients with combined mitral-aortic failure and left-sided ventriculomegaly?
Maximal preservation of mitral subvalvular structures, particularly anterior chord translocation with posterior leaflet preservation, improves left ventricular morphometry and contractility in patients undergoing combined mitral-aortic valve replacement.
May support subvalvular preservation in combined valve surgery; hypothesis-generating pending randomized confirmation.
Objective. The studying of possibilities of procedures, directed on preservation of left ventricle while doing a mitral valve prosthesis in operative correction of combined mitral-aortal failure. Materials and methods. In the analysis the results of surgical treatment of 340 patients, suffering combined mitral-aortal failure and a left-sided ventriculomegaly, who were operated in N. M. Amosov National Institute of Cardio-Vascular Surgery NAMS of Ukraine, were included. In all the patients a mitral valve prosthesis in combination with the aortal failure correction (prosthesis) was performed. In 83 patients the mitral valve prosthesis with complete preservation of posterior flap (Group A) was conducted, in 97 - with translocation of chords with papillar muscles of anterior flap in combination with posterior flap (Group B), in 160 - without preservation of the undervalvular apparatus (Group C). Definitely-systolic index of left ventricle in Groups A, B and C have constituted (87.4 ± 10.5), (88.4 ± 11.1) and (89.4 ± 11.5) ml/m2 accordingly; left ventricular ejection fraction have constituted 0.51 ± 0.03, 0.5 ± 0.03 and 0.51 ± 0.03 accordingly. Results. In Group A on a hospital stage 2 (2.5%) patients died, in Group B - 2 (2.1%) patients, and in Group C - 5 (3.1%). Definitely-systolic index of left ventricle on the tenth-eleventh postoperative day in Groups A, B and C have constituted (74.3 ± 9.8), (69.4 ± 8.2) and (76.4 ± 9.2) ml/m2 accordingly, while in late follow-up period - (55.4 ± 8.4), (49.4 ± 7.2) and (62.4 ± 7.2) ml/m2 accordingly. The left ventricle ejection fraction on the tenth-eleventh postoperative day in Groups A, B and C have constituted 0.54 ± 0.03, 0.55 ± 0.03 and 0.53 ± 0.03 accordingly, and in late follow-up period - 0.55 ± 0.03, 0.57 ± 0.03 and 0.54 ± 0.03 accordingly. Conclusion. In the left-sided ventriculomegaly and combined mitral-aortal failure the a maximal preservation of undervalvular structures of mitral valve, while its prosthesis performance, constitutes a serious component, which leads to improvement of morphometric indices of left ventricle on hospital stage and in follow-up period as well.
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Bolshak et al. (2020) conducted a cohort in Combined mitral-aortic valve disease with left ventriculomegaly (n=340). Mitral valve replacement with preservation of subvalvular structures (posterior leaflet preservation with or without anterior chord translocation) vs. Mitral valve replacement with complete excision of the subvalvular apparatus was evaluated on Left ventricular end-systolic index in late follow-up.
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