Key result
Thrombolytic therapy with urokinase resulted in total and rapid dissolution of an intracardiac thrombus in a premature infant, with no hemorrhagic complications.
Why the study?
Does urokinase therapy safely dissolve intracardiac thrombus in a premature infant?
Case Report (n=1)
Does urokinase therapy safely dissolve intracardiac thrombus in a premature infant?
Urokinase therapy may be a safe and effective treatment for intracardiac thrombus associated with central venous catheters in premature infants.
Should not yet change practice for intracardiac thrombus in premature infants; hypothesis-generating case requiring prospective validation.
A 670 g premature infant is described in whom an intracardiac thrombus was documented. This thrombus formation probably resulted as a complication of an indwelling right atrial catheter. Thrombolytic therapy with urokinase was instituted, resulting in total and rapid dissolution. No hemorrhagic complications resulted. We believe that this particular thrombolytic therapy is safe and effective and should be considered when facing this particular complication.
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Suárez et al. (1989) conducted a case report in Intracardiac thrombus (n=1). Urokinase was evaluated on Thrombus dissolution and hemorrhagic complications. Thrombolytic therapy with urokinase resulted in total and rapid dissolution of an intracardiac thrombus in a premature infant, with no hemorrhagic complications.
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