Laboratory study uncovers phosphate limitation sensing via PitA and PhoB in Pseudomonas aeruginosa, suggesting potential pathways for targeting chronic bacterial infections.
Pseudomonas aeruginosa is an opportunistic pathogenic bacterium that causes acute and chronic infections in humans. The type VI secretion systems (T6SSs) have been shown to associate with chronic infections. Understanding the mechanism used by the bacteria to sense environmental signals and regulate virulence factors will provide clues for developing novel effective treatment strategies. Here, we demonstrate a relationship between a phosphate transporter and the T6SSs and reveal a novel regulatory pathway that senses phosphate limitation and controls bacterial virulence factors in P. aeruginosa.
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Zhao et al. (2023) studied this question.
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